ABSTRACT
Background: Now a day’s melasma is a common pigmentarysyndrome among Asians and treatment is challenging. Oraltranexamic acid (TA) has materialized as a potential treatmentfor refractory melasma.Objective: In this study our main objective is to evaluateefficacy of oral tranexamic acid over melasma.Method: This opened clinical trial study was carried out atTertiary medical hospital Dhaka from June 2016 to July 2018where informed consent was sought from the total 120 patientsto take part in the study. At the baseline visit, history ofmelasma regarding length of time present, relationship topregnancy, oral contraceptive, drug history were noted.Result: During the experiment, maximum patients belong to21-25 years age group and percentage of female were 82%higher than male. Also, after 6 months follow up of 250mgdose of tranexamic acid (TA) treatment result, where patientsrating for excellent, good, fair, and poor outcome accounted21% patients, 66%, 13%, and 11 % patient, respectively.Conclusion: From our result and analysis we can say that,oral TA can be a very much effective treatment for refractorymelasma. Careful screening for personal and familial riskfactors for thromboembolism should be done beforeintroduction.